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What they measured: Senescent cell elimination increased right ventricular systolic pressure and the right ventricular hypertrophy index It increased vessel remodelling , with higher counts of dividing proliferating vascular cells in both normoxia and hypoxia It markedly depleted pulmonary endothelial cells , which comprise around 30% of lung senescent cells under normal conditions Pulmonary haemodynamic deterioration and endothelial cell loss occurred in serotonin-transporter-overexpressing mice given either ABT263 or FOXO4-DRI In monocrotaline rats, ABT263 gave a slight benefit at one week and then aggravated pulmonary hypertension at three weeks The authors’ own conclusion “Elimination of senescent P-ECs by senolytic interventions may worsen pulmonary hemodynamics