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Furthermore, IL-17 enhances osteoblast-mediated bone resorption by promoting the activity of receptor activator of nuclear factor-kappa B ligand (RANKL), macrophage colony-stimulating factor (M-CSF), and prostaglandin E2 (PGE2), thereby increasing cathepsin K (CTSK) and MMP expression (Zhang F

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Moreover, the immediate presentation of BPC-157 before injury may have also reduced the damage in murine models subjected to a force impulse