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(b) chronic daily treatment with l-Car (100 mg/kg) caused significant attenuation in seizure stage and duration and reversed the PTZ-induced alterations in the redox sate and the expression of caspase-3, β-catenin and more upregulation of Hsp 70 expression in the rat hippocampal CA3 region

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It is theorized that the downregulation of autophagy is related to the loss of heterozygosity across fumarate hydrase (FH) mutations that are found in uterine fibroids [35]