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A superimposition of our structure with the crystal structure (PDB ID: 2UZX) suggests that, upon the tethering of the N-terminal segment to the PSI and IPT1 domain of c-MET, the entire stalk region of c-MET rotates outward by ~20° (the pivot point is located at the linker between PSI and IPT1 domains), resulting in a more extended conformation (Supplementary Fig