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4) This product was manufactured in a facility that processes eggs, dairy, buckwheat, peanuts, soybeans, wheat, mackerel, crab, shrimp, pork, peaches, tomatoes, walnuts, chicken, beef, squid, shellfish, and pine nuts

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Pro-inflammatory cytokines drive the expression of these catabolic factors in chondrocytes through the activation of transcription factors such as HIF-2α 32 and NF-κB 79