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Genotoxic stresses in the microenvironment (including ROS, chemotherapeutic agents or radiation) can induce DNA damage in macrophages, which subsequently regulates their immune phenotype and function through activation of the cGAS-STING pathway or PARP-dependent repair pathways (91)

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Keeping the vial in its original box or a dark container inside the fridge is a simple way to maintain its potency