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It is well-established that an increase in levels of harmful metabolites including trimethylamine N-oxide (TAMO), indoxyl sulfate, and p -cresyl sulfate are associated with renal fibrosis, endothelial dysfunction, a decline in the estimated glomerular filtration rate (eGFR), cardiovascular complications, and increased mortality and morbidity in CKD ( p -cresyl sulfate and indoxyl sulfate concentrations in CKD patients ( Figure 1 The composition of the gut microbiota can be altered by therapeutic dietary interventions and intake of probiotics, and so dietary interventions and probiotics intake can be used to improve CKD outcomes ( p -cresyl sulfate and increases the diversity of both butyrate-forming bacteria such as Coprococcus and Roseburia , and the levels of anti-inflammatory bacteria like Blautia and Faecalibacterium ( While the gut is the main repertoire of microbes and the most studied site to date, urine and blood also harbor different types of microbes and microbial signatures in both healthy and disease conditions ( Our manuscript will focus on the relationship between the human microbiome and its products in the CKD pathophysiology and modulating the gut microbiota as a therapeutic strategy for CKD treatment

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ABSTRACT In an era where electronic advancements surge forward at an unprecedented pace, public apprehension surrounding the health ramifications of radio-frequency (RF) radiation intensifies