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The most dramatic result (mice returning to a body composition indistinguishable from lean age-matched animals) came from combining the inhibitor with a low-fat diet switch, and that study did not include a drug-alone arm
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They may be worth considering if: Your dog is dealing with chronic inflammation or joint problems You're looking for a recovery aid after surgery or injury You want a natural option to complement other treatments Your pet has plateaued with standard care However, they shouldn’t replace foundational health strategies like proper nutrition, exercise, and routine veterinary checkups