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When participants were started directly at 8 mg instead of titrating from 1 mg, GI symptom rates nearly doubled

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B-cell specific ablation of ChAT increases the mortality of mice subjected to partial hepatectomy compared to their wildtype counterpart, due to dysregulation of α7nAChR expressing Kupffer cells and CD8 + T cells, limiting their regenerative capacity and producing harmful IFN-γ, respectively (112)