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One common SLC1A5 inhibitor, GPNA, along with its derivative V-9032, exerts anti-tumor effects by blocking Gln uptake, inhibiting cell proliferation, and disrupting the intracellular redox state

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Based on this insight, a promising new drug targeting the alphaVbeta3 integrin affecting IGF-I signaling in smooth muscle cells has been found to inhibit the development of atherosclerotic lesions in diabetic pigs (85)